Monoclonal gammopathy of renal significance
نویسندگان
چکیده
Summary Monoclonal gammopathy of renal significance (MGRS) encompasses a group kidney disorders in which monoclonal immunoglobulin secreted by B cell or plasma clone causes damage, without meeting hematological criteria for malignancy. The underlying disorder patients with MGRS is generally consistent undetermined (MGUS). Because the wide spectrum MGRS-associated diseases, defined through location and mechanism injury, it often challenging to establish right diagnosis. Kidney biopsy must be considered early; hence, close cooperation between hematologist nephrologists crucial diagnosis treatment from beginning prevent irreversible organ damage. Anti B‑cell plasma-cell directed therapy cytostatic immunomodulatory agents can save ameliorate function significantly. This underlined fact that, untreated, disease shows early recurrence after transplantation.
منابع مشابه
Monoclonal gammopathy of renal significance: Diagnostic workup
The clinical spectrum of diseases associated with monoclonal gammopathies is wide and they are most commonly the consequence of renal deposition of monoclonal immunoglobulin or its components. The differential diagnosis is difficult and renal biopsy is essential. To distinguish many of these pathologies is necessary to use techniques that are not always available, even in tertiary central hospi...
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ژورنال
عنوان ژورنال: Memo – Magazine of European Medical Oncology
سال: 2021
ISSN: ['1865-5041', '1865-5076']
DOI: https://doi.org/10.1007/s12254-020-00671-4